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XENICAL DRUG INFORMATION

ORLISTAT - ORAL (OR-lih-stat)

COMMON BRAND NAMES: Xenical®

USES

Xenical is used along with a reduced-calorie diet to help significantly overweight people lose weight. It also helps to prevent regaining the weight which was previously lost. Xenical (orlistat) works by blocking some of the fat which is normally digested by the intestine.

HOW TO USE

Xenical (orlistat) is taken by mouth, usually three times a day during (or up to one hour after) each main meal that contains fat. Your daily intake of protein, fat, and carbohydrate should be evenly spread out over three main meals. If a meal is missed or contains no fat, skip that dose of Xenical. Because Xenical can interfere with absorption of fat-soluble vitamins (A, D, E, K), it is recommended you take a daily multivitamin supplement containing these nutrients. Take the multivitamin at least 2 hours before or 2 hours after taking Xenical (e.g., at bedtime). The effects of Xenical may begin as soon as 1 or 2 days after treatment begins. Noticeable weight loss may take longer.

XENICAL SIDE EFFECTS

If these Xenical side effects persist or worsen, call your doctor promptly.

• oily /fatty stool
• oily spotting
• intestinal gas with discharge
• bowel movement urgency
• poor bowel control
• headaches

Intestinal side effects, like oily stool, may intensify if you exceed your daily dietary fat allowance.

If you notice other Xenical side affects not listed above, contact your doctor or pharmacist.

XENICAL PRECAUTIONS

Tell your doctor your medical history, including:

• allergies
• digestive disorders (cholestasis or malabsorption)
• low thyroid function (hypothyroidism)
• other metabolism problems (such as, hyperoxaluria or oxalate kidney stones)

Xenical should not be used if you have anorexia nervosa or a bulimia-type eating disorders.

XENICAL and PREGNANCY

Before using Xenical, tell your doctor if you are pregnant. The manufacturer does not recommend Xenical during pregnancy.

XENICAL and BREAST FEEDING

It is not known whether Xenical is excreted into breast milk. Because of the potential risk to the baby, it is not recommended to breast-feeding while using this drug. Consult your doctor before breast-feeding.

XENICAL DRUG INTERACTIONS

Tell your doctor about all prescription and over-the-counter medication you use, especially:

• blood thinners (such as, warfarin)
• cyclosporine
• drugs for diabetes (such as, insulin)
• other drugs used for weight loss

Cyclosporine should be taken at least 2 hours before or after Xenical (orlistat) to assure maximum absorption of the cyclosporine into your bloodstream.

Do not start or stop any medicine without your doctor's approval.

XENICAL OVERDOSE

If a Xenical overdose is suspected, your local poison control center (1-800-222-1222) or emergency room (911) immediately.

NOTES

Do not share your Xenical with anyone.

Follow your nutritional, doctor-approved, reduced-calorie diet which should contain about 30 percent calories from fat.

Exercise is also recommended. However, first consult your doctor.

MISSED XENICAL DOSE

If you miss a dose of Xenical, take it as soon as you remember. However, if it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not take a double dose to catch up.

STORAGE

Store Xenical at room temperature (77 degrees F, 25 degrees C) away from light and moisture. Do not store in the bathroom.

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