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PROTOPIC DRUG INFORMATION

GENERIC PROTOPIC: Tacrolimus

COMMON BRAND NAMES: Protopic®

PROTOPIC TACROLIMUS USE

Protopic (Tacrolimus) ointment is used to treat the symptoms of atopic dermatitis, a skin disease also know as eczema. It is prescribed when a patient cannot use other topical medications or whose condition has not improved with another medication.

Protopic is in the immunosuppressants class of medications. It works to stop the immune system from producing the substances which cause eczema.

HOW TO USE PROTOPIC

• Apply Protopic ointment to the affected skin, usually twice a day. To help remember, it is best to apply it at the same time every day.
  
  
• Use Protopic exactly as directed, following the directions on the prescription label. Do not use more or less of the ointment than prescribed. Ask your doctor of pharmacist any question you may have.
  
  
• Do not use Protopic regularly for a long period of time. Use only when you have eczema symptoms and for one additional week after your skin clears up. Call your doctor when the symptoms are gone to ask if you should stop using Protopic. Also call if the symptoms return to ask if you should start using it again.
  
  
• It may take up to six weeks for the symptoms to completely subside. If they are still present after six weeks of applying Protopic ointment, call your doctor. Also call your doctor if the symptoms get worse after using Protopic for a few weeks.

HOW TO APPLY PROTOPIC

• Before applying Protopic ointment, wash your hands. If your have just taken a shower or bath, be sure your skin is completely dry before applying.
  
  
• Apply sparingly in a thin film. Rub in gently. Be careful not to get it in your eyes or mouth.
  
  
• Do not use cosmetics or other skin treatments on the affected area unless your doctor approves.
  
  
• Do not apply a bandage or wrap the treated area.
  
  
• Wash your hands after applying Protopic, unless you are treating eczema on your hands.

PROTOPIC SPECIAL PRECAUTIONS

Before you use Protopic ointment,

• Tell your doctor and pharmacist if you are allergic to
  
  
  • tacrolimus ointment, injection, or capsules (Prograf)
  • any other medications
    
    
• Tell your doctor and pharmacist about any prescription and over-the-counter medications you take, including nutritional supplements, vitamins, and herbal products, especially:
  
  
  • antifungals such as
    
    
    • ketoconazole (Nizoral)
    • fluconazole (Diflucan)
    • itraconazole (Sporanox)
      
      

  IMPORTANT NOTE: This information is supplemental only, not a substitute for, the expertise and judgment of your physician, pharmacist or other healthcare provider. It should not be seen as an indication that use of the medicine is effective, safe or appropriate for you. Consult your doctor before this medicine is used

  • calcium channel blockers such as
    
    
    • verapamil (Calan, Covera, Isoptin, Verelan)
    • diltiazem (Cardizem, Dilacor, Tiazac)
      
      
  • erythromycin (E.E.S., E-Mycin, Erythrocin)
  • cimetidine (Tagamet)
  • other ointments, creams, or lotions

    Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

• Tell your doctor if you
  
  
  • have a skin infection
    
    
  • have or have ever had Netherton's syndrome (a skin disease)
    
    
  • have or have ever had cancer
    
    
  • are being treated with any form of light therapy such as UVA, UVB. or phototherapy
    
    
• If you are having surgery, (this includes dental surgery), tell the doctor or dentist that you are using Protopic ointment
  
  
• If you consume alcohol, ask your doctor if it is safe to do while you are using Protopic ointment. Alcohol can cause your skin or face to become flushed or red and feel hot.
  
  
• Avoid unnecessary or prolonged exposure to sunlight, both natural and artificial (as with sun lamps and tanning beds). Wear protective clothing, sunscreen, and sunglasses. If your skin is exposed to sunlight, Protopic ointment may increase the risk of developing skin cancer.
  
  
• Avoid exposure to viruses, especially chicken pox and shingles. If you do become exposed to one of these viruses while using Protopic ointment, call your doctor immediately.

PROTOPIC and PREGNANCY

Tell your doctor if you are pregnant or trying to get pregnant. If you become pregnant while using Protopic ointment, call your doctor.

PROTOPIC and BREAST FEEDING

Tell your doctor if you are breast feeding.

SPECIAL DIETARY INSTRUCTIONS

Ask your doctor about drinking grapefruit juice while you are taking Protopic ointment.

MISSED DOSES

If you forget to apply a dose Protopic ointment, apply it as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue the next dose. Do not apply extra ointment to make up for a dose you missed.

PROTOPIC SIDE EFFECTS

Protopic ointment may cause side effects. Tell your doctor if any of these side effects are severe or do not go away:

• flu-like symptoms
• headache
• itching
• muscle pain
• skin stinging, burning, redness or soreness
• tingling skin

Some Protopic side effects can be serious. These symptoms are uncommon, but if you experience either of them, call your physician immediately:

• rash
• swollen glands

Some patients developed lymph node cancer or skin cancer while they were using Protopic ointment. It is unknown if Protopic ointment caused the cancer to develop or if the patients would have developed cancer anyway, even if they had not used Protopic ointment. Talk to your doctor about these risks.

Protopic ointment may cause other side effects. Call your doctor if you have any unusual problems while using this medication.

PROTOPIC OINTMENT OVERDOSE

In case of an overdose, call your local poison control center (800-222-1222).

If the victim is not breathing or has collapsed, call local emergency services at 911.

OTHER INFORMATION

Keep all appointments with your doctor.

Do not let anyone else use your Protopic ointment. Do not use Protopic ointment for a skin condition other than the one for which it was prescribed.

Ask your pharmacist any questions about refilling your prescription.

STORAGE

Keep Protopic ointment in the container it came in, tightly closed, and out of reach of children. Store it at room temperature, away from excess heat and moisture. Do not store in the bathroom.

Discard any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of Protopic ointment.

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