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ANTIVERT DRUG INFORMATION

COMMON BRAND NAME: ANTIVERT®

WHAT IS ANTIVERT?

Buclizine, meclizine and cyclizine are used to treat and prevent dizziness, nausea and vomiting associated with motion sickness, and vertigo.

Some of these medications are available only with a doctor's prescription. Others do not need a prescription. However, your physician may give you special instructions on the proper dose for you to take with your medical condition. They are available in the following doses and forms:

Oral

• Cyclizine
  • Tablets ( U.S.)
• Buclizine
  • Chewable tablets
• Meclizine
  • Chewable tablets ( U.S. and Canada)
  • Tablets ( U.S.)

Parenteral (by intramuscular or intravenous injection)

• Cyclizine
  • Injection ( Canada)

CONCERNS

Carefully read and follow any precautions on the label if you are taking this medicine without a prescription.

For buclizine, meclizine, and cyclizine:

Children -There is no real information comparing use of cyclizine, buclizine, and meclizine in children as compared to other age groups. But we find that children may be especially sensitive to the anticholinergic effects of these medicines, like dryness of nose, mouth, and throat.

Older adults - There is no real information comparing the use of cyclizine, buclizine, and meclizine in older adults with use in other age groups. Not many medicines have been studied specifically in the elderly. It is not known if they work exactly the same as in younger adults. Older people may be especially sensitive to the anticholinergic effects of these medicines, like difficult urination, constipation, and dryness of mouth, nose, and throat.

Allergies - Inform your physician if you have ever had any unusual or allergic reaction to buclizine, meclizine, or cyclizine. Also inform them if you are allergic to any other substances, such as foods, dyes or preservatives.

Antivert Drug Interactions - There are some medicines that should never be used together. There are other cases where two medicines used together will have an interaction. It may still be safe to use both, but your doctor may need to change the doses or take other precautions.

If taking cyclizine, buclizine, or meclizine, it is especially important that your doctor know if you are taking the following:

• central nervous system depressants (CNS)
• other medicines that make you drowsy or less alert
• Tricyclic antidepressants - used with buclizine, cyclizine, or meclizine may increase side effects of either.

ANTIVERT and PREGNANCY

Tell your doctor if you are pregnant or trying to get pregnant. Studies have not proven that these medicines cause birth defects or other problems in humans. However, research using animals has shown that buclizine, cyclizine, and meclizine given in large doses, many times the usual human dose, can cause birth defects like cleft palate.

ANTIVERT and BREAST FEEDING

Tell your doctor if you are breast feeding. These medicines may pass into breast milk, but they have not been shown to cause problems in nursing babies. However, these medicines tend to decrease the secretions of the body. It is possible that the flow of breast milk may be decreased in some patients.

IMPORTANT NOTE: This information is intended to be supplemental only and not a substitute for the expertise and judgment of your doctor, pharmacist or other healthcare professional. It should not be seen as an indication that use of this drug is effective, safe or appropriate for you. Consult your doctor before you use this medication

PRECAUTIONS

Tell your doctor if you have any other medical problems.

Cyclizine or meclizine use can result serious breathing problems in patients who have any of these conditions

• emphysema
• asthma
• bronchitis
• other chronic lung disease

Buclizine, meclizine, or cyclizine may make this conditions worse

• urinary tract blockage

Cyclizine may make this condition worse

• heart failure

Also tell your doctor if you have:

• enlarged prostate
• glaucoma
• intestinal blockage

PROPER USE

These medicines are used to prevent or relieve the symptoms of motion sickness or vertigo, which is dizziness from other medical problems. Take these medicines only as directed. Do not take more often or take a larger dose than stated on the prescription label or ordered by your doctor. Side effects may be increased.

OTHER USES

After a medication has been approved for marketing for a particular use, experience may indicate that it is can also be useful for other medical conditions. Although these uses are not listed with product labeling information, some of these medications are used in some patients to prevent the following medical problems:

• Nausea and vomiting after surgery
• Nausea and vomiting after cancer radiation treatment

ANTIVERT DOSAGE

Antivert tablets are available in 12.5 mg and 25 mg. The dosage will be different for different patients. Follow your doctor's instructions or the directions on the prescription label. These are only the average doses of buclizine, cyclizine, or meclizine. If your doctor has given you a different dose, do not change it.

Buclizine - To prevent motion sickness:

• Oral dosage (chewable tablets):
  • Adults and teenagers - Usually 50 milligrams (mg), 30 minutes before traveling. May be repeated every 4 - 6 hours if needed. Do not take more than 150 mg in one day.
    
    
  • Children - Your doctor will determine the dose.

For cyclizine - To prevent and treat motion sickness:

• Oral dosage (tablets):
  
  
  • Adults and teenagers - Usual dose is 50 milligrams (mg), 30 minutes before traveling. May be repeated every 4-6 hours if it is needed. Do not take more than 200 mg one day.
    
    
  • Children 6-12 years of age - Usual dose is 25 mg, 30 minutes before traveling. May be repeated every 6-8 hours if it is needed. Do not take more than 75 mg in one day.
    
    
  • Children up to 6 years of age - Follow your doctor's advise on use and dose.
    
    
• Injection dosage:
  
  
  • Adults and teenagers - Usual dose of 50 mg is injected directly into a muscle every 4-6 hours as needed.
    
    
  • Children - Dose will be based on their body weight. The most usual dose of 1 mg per kilogram (0.45 mg per pound) of body weight is injected directly into a muscle, three times a day as needed. Your doctor will determine the dose.

For meclizine - Oral dose forms (tablets and chewable tablets):

• To prevent and treat motion sickness:
  
  
  • Adults and children 12 and older -The usual dose is 25 to 50 milligrams (mg), taken 1 hour before travel. May be repeated every 24 hours if needed.
    
    
  • Children up to 12 - Doctor will determine dosage.
    
    
• To prevent and treat vertigo (dizziness):
  
  
  • Adults and children 12 and older -The usual dose is 25 to 100 milligrams (mg) a day as needed. These doses are divided into smaller ones, taken throughout the day.
    
    
  • Children up to 12 - Doctor will determine dosage.

PRECAUTIONS

Skin test for allergies may be affected by these medicines. Tell your doctor if you will be having these tests.

If you take buclizine, cyclizine, or meclizine tell your doctor if:

• you drink alcohol
• you are taking other CNS depressants (medicines that make you drowsy or less alert), like:
  
  
  • anesthetics, including some dental anesthetics
  • antihistamines or medications for hay fever other allergies or for colds
  • seizure medication
  • muscle relaxants
  • tranquilizers, sedatives, or sleeping medication
  • prescription pain medication
  • narcotics
  • barbiturates

These medications may cause drowsiness or decrease on alertness. Be sure you know how you will react before you drive, use machines, or do anything else that requires mental alertness.

Cyclizine, buclizine and meclizine may result in dry mouth. Candy or gum, ice bits melted in your mouth, or a saliva substitute may give temporary relief. If your mouth continues to feel dry for over two weeks, inform your doctor or dentist. Constant dry mouth may increase the risk of dental diseases. These may include gum disease, tooth decay, and fungus infections.

ANTIVERT SIDE EFFECTS

Not all of these Antivert side effects have been reported for each of these medicines. They have been reported for at least one of them, however. Since cyclizine, buclizine, and meclizine are similar, any of these side effects may occur with any of those medicines.

These Antivert side affects, if they occur, may go away as your body adjusts to the medicine. However, tell your doctor if they continue or are bothersome:

• More common side effects:
  • Drowsiness 
    
    
• Less common or rare side effects:
  • fast heartbeat
  • dizziness
  • blurred or double vision
  • diarrhea
  • constipation
  • difficult or painful urination
  • dryness of mouth, nose, and throat
  • headache
  • loss of appetite
  • upset stomach 
  • skin rash
  • restlessness, nervousness, or trouble in sleeping

If you have any other side effects not listed, inform your doctor.

MISSED DOSES

If you take Antivert regularly and miss a dose, take the missed dose as soon as you remember it. But if it is near time for the next dose, skip the missed dose, then continue with the regular dosing schedule. Do not double your doses.

STORAGE

Keep out of the reach of children.

Store these medications away from heat and direct light.

Heat and/or moisture can cause the medicine to break down. Therefore, do not store in the bathroom, near a sink or in other damp places.

Discard outdated medicine or medicine no longer needed. Be sure that any discarded medication is not in the reach of children.

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