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ZYLOPRIM DRUG INFORMATION

GENERIC ZYLOPRIM®: Allopurinol

ZYLOPRIM USES

Zyloprim (Allopurinol) is used to treat kidney stones, gout, and high levels of uric acid in the body caused by some cancer medications. Zyloprim is in a class of medications called xanthine oxidase inhibitors. It works by reducing the production of uric acid in the body. Gout attacks or kidney stones may be caused by high levels of uric acid. Zyloprim is used to prevent gout attacks. It is not used to treat them once they occur.

ZYLOPRIM DOSAGE, HOW TO USE

Zyloprim tablets are usually taken once or twice a day after a meal. To make it easier to remember, take Zyloprim around the same time each day.

Read and follow the directions on your prescription label carefully. Ask your pharmacist or doctor to explain any part you do not understand.

Take Zyloprim exactly as prescribed. Do not take it more often or take more or less of it than prescribed by your doctor.

Probably your doctor will start you on a low dose of Zyloprim and gradually increase the dose, not more than once a week.

It may be several months or longer before you feel the full benefit of Zyloprim. Zyloprim may actually increase the number of gout attacks during the first few months that you take it. It should eventually prevent attacks. Your doctor may prescribe colchicine or another medication to prevent gout attacks for the first few months you take Zyloprim. Continue to take Zyloprim even if you feel better. Do not stop taking Zyloprim without discussing it with your doctor.

OTHER USES

Zyloprim is also used to treat certain infections, seizures, and pain caused by pancreas disease. It is also used to improve survival chances after bypass surgery, prevent rejection of kidney transplants, and reduce ulcer relapses.

ZYLOPRIM DRUG INTERACTIONS AND SPECIAL PRECAUTIONS

Before taking Zyloprim:

• Tell your doctor and pharmacist if you are allergic to Zyloprim or any other medications.
  
  
• Tell your doctor about any prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking. Be sure to mention any of the following:
  
  
  • amoxicillin (Amoxil, Trimox)
  • ampicillin (Principen, Polycillin)
  • anticoagulants (blood thinners) such as warfarin (Coumadin)
  • chemotherapy drugs such as mercaptopurine (Purinethol) and cyclophosphamide (Cytoxan)
  • chlorpropamide (Diabinese)
  • diuretics (water pills)
  • medications that suppress the immune system such as cyclosporine (Neoral, Sandimmune) and azathioprine (Imuran)
  • other medications for gout such as sulfinpyrazone (Anturane) and probenecid (Benemid)
  • tolbutamide (Orinase)

  Your doctor may need to adjust the dosage of your medications or monitor you carefully for side effects.

Tell your doctor if you have or have ever had liver disease, kidney disease or heart failure.

Zyloprim may make you drowsy. Do not operate machinery or drive a car or until you know how this medication affects you.

Alcohol may decrease the effectiveness of Zyloprim. Discuss with your doctor the safe use of alcoholic beverages while you are taking Zyloprim.

ZYLOPRIM and PREGNANCY

Tell your doctor if you are pregnant or trying to get pregnant.

ZYLOPRIM and BREAST FEEDING

Tell your doctor if you are breast feeding.

SPECIAL DIETARY PRECAUTIONS

Drink at least eight glasses of water or other fluids each day while taking Zyloprim unless otherwise directed by your doctor.

MISSED DOSES

Take a missed Zyloprim dose as soon as you remember it. However, if it is close to the time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take double the dose to make up for a missed one.

ZYLOPRIM SIDE EFFECTS

Tell your doctor if any of these Zyloprim side effects are severe or do not go away:

• diarrhea
• drowsiness
• upset stomach

SERIOUS ZYLOPRIM SIDE AFFECTS: The following Zyloprim side affects are uncommon, but if you experience any of them, contact your doctor immediately:

• skin rash
• fever, sore throat, chills, and other signs of infection
• itching
• irritation of the eyes
• loss of appetite
• painful urination
• blood in the urine
• swelling of the lips or mouth
• unexpected weight loss

Zyloprim may cause other side effects. Call your doctor if you experience any unusual problems while taking Zyloprim.

STORAGE

Keep Zyloprim in the container it came in, tightly closed, out of reach of children. Store it at room temperature, away from excessive heat and moisture. Do not store in the bathroom.

Discard any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of Zyloprim.

OTHER INFORMATION

Keep all doctor and laboratory appointments. Your doctor will order certain lab tests to check your body's response to Zyloprim.

Do not let anyone else take your Zyloprim medication. Ask your pharmacist any questions you have about refills.

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